Peer-Reviewed Journal Details
Mandatory Fields
Yang, G;O'Duill, M;Gouverneur, V;Krafft, MP
2015
July
Angewandte Chemie (International ed. in English)
Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas
Published
Altmetric: 2WOS: 6 ()
Optional Fields
MICROBUBBLES RECOGNITION MONOLAYER CHEMISTRY THERAPY HYPOXIA SIZE
54
8402
8406
Perfluorohexane gas when introduced in the air atmosphere above a film of phospholipid self-supported on an aqueous solution of C2F5-labeled compounds causes the recruitment and immobilization of the latter in the interfacial film. When the phospholipid forms a liquid-condensed Gibbs monolayer, which is the case for dipalmitoylphosphatidylcholine (DPPC), the C2F5-labeled molecule remains trapped in the monolayer after removal of F-hexane. Investigations involve bubble profile analysis tensiometry (Gibbs films), Langmuir monolayers and microbubble experiments. The new phenomenon was utilized to incorporate a hypoxia biomarker, a C2F5-labeled nitrosoimidazole (EF5), in microbubble shells. This finding opens perspectives in the delivery of fluorinated therapeutic molecules and biomarkers.
1433-7851
10.1002/anie.201502677
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