Peer-Reviewed Journal Details
Mandatory Fields
Mizuta, S;Stenhagen, ISR;O'Duill, M;Wolstenhulme, J;Kirjavainen, AK;Forsback, SJ;Tredwell, M;Sandford, G;Moore, PR;Huiban, M;Luthra, SK;Passchier, J;Solin, O;Gouverneur, V
2013
June
Organic Letters
Catalytic Decarboxylative Fluorination for the Synthesis of Tri- and Difluoromethyl Arenes
Published
Altmetric: 1WOS: 94 ()
Optional Fields
MEDICINAL CHEMISTRY CARBOXYLIC-ACIDS XENON DIFLUORIDE PET DETECTION FLUORODECARBOXYLATION RADIOSYNTHESIS BIS(TRIFLATE) HYPOXIA MARKER
15
2648
2651
Treatment of readily available alpha,alpha-difluoro- and alpha-fluoroarylacetic acids with Selecffluor under Ag(I) catalysis led to decarboxylative fluorination. This operationally simple reaction gave access to tri- and difluoromethylarenes applying a late-stage fluorination strategy. Translation to [F-18]labeling is demonstrated using [F-18]Selectfluor bis(triflate), a reagent affording [F-18]tri- and [F-18]difluoromethylarenes not within reach with [F-18]F-2.
1523-7060
10.1021/ol4009377
Grant Details
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