Peer-Reviewed Journal Details
Mandatory Fields
Irvine, MW;Fang, GY;Eaves, R;Mayo-Martin, MB;Burnell, ES;Costa, BM;Culley, GR;Volianskis, A;Collingridge, GL;Monaghan, DT;Jane, DE
2015
June
Synthesis-Stuttgart
Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-D-aspartate Receptor Allosteric Modulators
Published
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Optional Fields
NMDA RECEPTOR DERIVATIVES ACIDS
47
1593
1610
9-Substituted phenanthrene-3-carboxylic acids have been reported to have allosteric modulatory activity at the N-methyl-D-aspartate (NMDA) receptor. This receptor is activated by the excitatory neurotransmitter L-glutamate and has been implicated in a range of neurological disorders such as schizophrenia, epilepsy and chronic pain, and in neurodegenerative disorders such as Alzheimer's disease. Herein, the convenient synthesis of a wide range of novel 3,9-disubstituted phenanthrene derivatives starting from a few common intermediates is described. These new phenanthrene derivatives will help to clarify the structural requirements for allosteric modulation of the NMDA receptor.
0039-7881
10.1055/s-0034-1380114
Grant Details
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