Peer-Reviewed Journal Details
Mandatory Fields
Murphy, PV,O'Brien, JL,Gorey-Feret, LJ,Smith, AB
2003
March
Tetrahedron
Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds
Published
()
Optional Fields
HIV-1 inhibitors aspartic acid carbohydrate based peptidomimetics STRUCTURE-BASED DESIGN IMMUNODEFICIENCY-VIRUS PROTEASE BETA-D-GLUCOSE CYCLIC PEPTIDE RHODOPEPTIN BIOLOGICAL EVALUATION DRUG DESIGN COMBINATORIAL LIBRARIES ALZHEIMERS-DISEASE NOVO DESIGN PEPTIDOMIMETICS
59
2259
2271
The synthesis of peptidomimetic inhibitors of HIV-1 protease based on 6-deoxy-6-aniino-beta-D-glucopyranoside and 6-deoxy-6-amino- beta-D-mannopyranoside scaffolds has been achieved. The inhibitors had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate based inhibitors of HIV-1 and other aspartic proteases. (C) 2003 Elsevier Science Ltd. All rights reserved.
DOI 10.1016/S0040-4020(03)00208-4
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