Peer-Reviewed Journal Details
Mandatory Fields
Cronin, L,Murphy, PV
2005
June
Organic Letters
Novel synthesis of castanospermine and 1-epicastanospermine
Published
()
Optional Fields
IN-SITU (+)-CASTANOSPERMINE DERIVATIVES 6-DEOXYHEX-5-ENOPYRANOSIDES (&)-CASTANOSPERMINE GLYCOSYLATION EPOXIDATION INHIBITION ALKALOIDS INFECTION
7
2691
2693
Polyhydroxylated indolizidines have potential for treatment of HIV, hepatitis C and HSV infection, multiple sclerosis, angiogenesis, cancer, and diabetes. A new synthetic approach to the title compounds from a 5-C-methoxypyranosyl azide has been developed. The route incorporates lid the aldol reaction and a novel catalytic reductive amination cascade to generate the indolizidine ring.
DOI 10.1021/ol0508577
Grant Details
Publication Themes