Peer-Reviewed Journal Details
Mandatory Fields
Walton, E,Hibar, DP,van Erp, TGM,Potkin, SG,Roiz-Santianez, R,Crespo-Facorro, B,Suarez-Pinilla, P,Van Haren, NEM,de Zwarte, SMC,Kahn, RS,Cahn, W,Doan, NT,Jorgensen, KN,Gurholt, TP,Agartz, I,Andreassen, OA,Westlye, LT,Melle, I,Berg, AO,Morch-Johnsen, L,Faerden, A,Flyckt, L,Fatouros-Bergman, H,Jonsson, EG,Hashimoto, R,Yamamori, H,Fukunaga, M,Preda, A,De Rossi, P,Piras, F,Banaj, N,Ciullo, V,Spalletta, G,Gur, RE,Gur, RC,Wolf, DH,Satterthwaite, TD,Beard, LM,Sommer, IE,Koops, S,Gruber, O,Richter, A,Kramer, B,Kelly, S,Donohoe, G,McDonald, C,Cannon, DM,Corvin, A,Gill, M,Di Giorgio, A,Bertolino, A,Lawrie, S,Nickson, T,Whalley, HC,Neilson, E,Calhoun, VD,Thompson, PM,Turner, JA,Ehrlich, S,Karolinska Schizophrenia Project
2017
May
Acta Psychiatrica Scandinavica
Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium
Published
Optional Fields
schizophrenia positive symptoms superior temporal gyrus cortical thickness ENIGMA FreeSurfer MRI scale for the assessment of positive symptoms positive and negative syndrome scale 1ST EPISODE SCHIZOPHRENIA AUDITORY VERBAL HALLUCINATIONS BIPOLAR DISORDER CEREBRAL-CORTEX 1ST-EPISODE SCHIZOPHRENIA PLANUM TEMPORALE THICKNESS PSYCHOSIS METAANALYSIS COMPREHENSION
135
439
447
ObjectiveBased on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia.MethodThis prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness.ResultsPositive symptom severity was negatively related to STG thickness in both hemispheres (left: (std) = -0.052; P = 0.021; right: (std) = -0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness.ConclusionOur findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.
10.1111/acps.12718
Grant Details
Publication Themes