Peer-Reviewed Journal Details
Mandatory Fields
Rawe, SL,Zaric, V,O'Boyle, KM,Murphy, PV
Bioorganic & Medicinal Chemistry Letters
N-Glycosyl-thiophene-2-carboxamides: Effects on endothelial cell growth in the presence and absence of bFGF - A significant increase in potency using per-O-acetylated sugar analogues
Optional Fields
endothelial cell proliferation angiogenesis bFGF glycoconjugates glycosyl amides thiophene-2-carboxamides ANGIOGENESIS BINDING CANCER DISACCHARIDES LIBRARY HEPARIN FGF-2
Inhibitors of endothelial cell proliferation are of interest in development of therapies for angiogenesis related disease. N-Glucosyl-thiophene-2-carboxamides have been synthesized and evaluated for their effects on proliferation in bovine aortic endothelial cells. Per-O-acetylated-N-glucosyl-thiophene-2-carboxamides showed improved inhibition of both serum and bFGF stimulated uptake of [H-3]thymidine, when compared to non-acetylated analogues. (C) 2005 Elsevier Ltd. All rights reserved.
DOI 10.1016/j.bmcl.2005.11.058
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