Peer-Reviewed Journal Details
Mandatory Fields
Li, J,Henman, MC,Atkinson, J,Fixon-Owoo, S,Tatlisumak, T,Shaw, GG,Doyle, KM
2006
March
Brain Research
The pre-ischaemic neuroprotective effects of the polyamine analogues BU43b and BU36b in permanent and transient focal cerebral ischaemia models in mice
Published
()
Optional Fields
BU43b BU36b polyamine NMDA receptor focal cerebral ischaemia middle cerebral artery occlusion ARTERY OCCLUSION ANTAGONIST N-1-DANSYL-SPERMINE MK-801 DIFFUSION EFFICACY SIZE RATS
1076
209
215
The present study investigated the neuroprotective potential of two novel polyamine analogues, BU43b and BU36b, when administered 30 min prior to cerebral ischaemia. Neuroprotection in a permanent and a transient focal cerebral ischaemia mouse model (induced by intraluminal middle cerebral artery occlusion (MCAO)) was investigated using a range of histological and behavioural assessments. In the permanent ischaemia model, BU43b reduced oedema and showed a trend towards reduction in %HLV (percentage hemisphere lesion volume) when administered at a dose of 30 mg/kg i.p. Following transient ischaemia, treatment with BU43b decreased the %HLV and reduced oedema when administered at 30 mg/kg. BU43b also improved the locomotor activity (LMA) in MCAO mice at both 20 mg/kg and 30 mgfkg doses. BU36b was less effective than BU43b in both the permanent and the transient models, with its most pronounced effect being a trend towards reduction in oedema in both models. These results demonstrate that BU43b administered 30 min before ischaemia provided a good level of neuroprotection in the two models of cerebral ischaemia used and may have potential as a neuroprotective treatment for stroke. (c) 2005 Elsevier B.V. All rights reserved.
DOI 10.1016/j.brainres.2005.12.097
Grant Details
Publication Themes