Peer-Reviewed Journal Details
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Reeve, JLV,Stenson-Cox, C,O'Doherty, A,Porn-Ares, I,Ares, M,O'Brien, T,Samali, A
2007
May
Biochemical And Biophysical Research Communications
OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(-/-) mice aortas
Published
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Optional Fields
apolipoprotein E cell death gene expression oxidative stress OxLDL smooth muscle cell LOW-DENSITY-LIPOPROTEIN SMOOTH-MUSCLE-CELLS BIFUNCTIONAL PROTEIN-DEFICIENCY OXIDIZED LDL GLUTATHIONE SYNTHESIS ENDOTHELIAL-CELLS OXIDATIVE STRESS APOLIPOPROTEIN-E MACROPHAGES INDUCTION
356
681
686
Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(-/-) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights reserved.
DOI 10.1016/j.bbrc.2007.03.027
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