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Joyce, DP,Murphy, D,Lowery, AJ,Curran, C,Barry, K,Malone, C,McLaughlin, R,Kerin, MJ
2017
October
Surgeon-Journal Of The Royal Colleges Of Surgeons Of Edinburgh And Ireland
Prospective comparison of outcome after treatment for triple-negative and non-triple-negative breast cancer
Published
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Breast cancer Triple-negative Non-triple-negative LOCOREGIONAL RECURRENCE CONSERVING THERAPY RADIATION-THERAPY SURVIVAL WOMEN PATTERNS
15
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Introduction: Triple-negative breast cancers (TNBC) are associated with a poor prognosis owing to an aggressive phenotype. We aimed to carry out a prospective study comparing management strategies and response to therapy in TNBC and non-TNBC patients.Methods: Data were obtained from a prospectively maintained database of patients treated for breast cancer.Results: A total of 142 TNBC and 142 age-, stage- and NPI-matched non-TNBC patients were treated. The difference in overall survival between the 2 groups was statistically significant (77% of TNBC patients alive at a mean follow-up of 32 months, versus 92% of non-TNBC patients at a mean follow-up of 38 months, P = 0.0 Log rank test). This survival difference was found to be independent of NPI (P = 0.0 Log rank test). Locoregional recurrence rates were similar between TNBC patients who were treated with wide local excision versus mastectomy (P = 0.449 Log rank test). A significant difference in survival was noted between TNBC patients who responded differentially to neoadjuvant chemotherapy (P = 0.035 Log rank test).Conclusion: Patients with TNBC have adverse outcomes despite aggressive treatment. The development of effective targeted therapies is essential for this breast cancer subtype. (C) 2016 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.
10.1016/j.surge.2016.10.001
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