Peer-Reviewed Journal Details
Mandatory Fields
Fagan, V,Bonham, S,Carty, MP,Aldabbagh, F
2010
January
Organic & Biomolecular Chemistry
One-pot double intramolecular homolytic aromatic substitution routes to dialicyclic ring fused imidazobenzimidazolequinones and preliminary analysis of anticancer activity
Published
()
Optional Fields
RADICAL CYCLIZATION HYDROGEN-PEROXIDE DT-DIAPHORASE ADDITIONS TOXICITY BENZIMIDAZOLES CYTOTOXICITY IMIDAZOLES EXPRESSION IODIDES
8
3149
3156
Bu3SnH/ 1,1'-azobis(cyclohexanecarbonitrile) (ACN)-mediated five, six, and seven-membered double alkyl radical cyclizations onto imidazo[5,4-f]benzimidazole and imidazo[4,5-f]benzimidazole are described. The quinone derivatives evaluated show selective toxicity towards human cervical (HeLa) and prostate (DU145) cancer cell lines (with negligible toxicity towards a normal human cell line, GM00637). Only the Fremy oxidation of the 6-aminoimidazo[5,4-f]benzimidazole gave iminoquinone, which showed high specificity towards the prostate cancer cell line (DU145).
DOI 10.1039/c003511d
Grant Details
Publication Themes