Peer-Reviewed Journal Details
Mandatory Fields
Harrison, NM,McDonnell, PF,O'Mahoney, DC,Kennedy, OD,O'Brien, FJ,McHugh, PE
2008
August
Journal Of Biomechanics
Heterogeneous linear elastic trabecular bone modelling using micro-CT attenuation data and experimentally measured heterogeneous tissue properties
Published
()
Optional Fields
trabecular cancellous voxel vertebra nanoindentation grey values mu CT FINITE-ELEMENT MODELS VERTEBRAL CANCELLOUS BONE MECHANICAL-PROPERTIES COMPUTED-TOMOGRAPHY INTRASPECIMEN VARIATIONS QUANTITATIVE CT MODULUS BEHAVIOR DENSITY ARCHITECTURE
41
2589
2596
High-resolution voxel-based finite element software, such as FEEBE developed at the NCBES, is widely used for Studying trabecular bone at the micro-scale. A new approach to determine heterogeneous bone tissue Material properties for computational models was proposed in this study. The specimen-specific range of tissue moduli across strut width was determined from nanoindentation testing. This range was mapped directly using linear interpolation to that specimen's micro-computed tomography (mu CT) grey value range as input material properties for finite element analysis. The method was applied to cuboid trabecular bone samples taken from eight, 4-year-old (skeletally mature) ovine L5 vertebrae. Before undergoing experimental uniaxial compression tests, the samples were mu CT scanned and 30 mu m resolution finite element models were generated. The linear elastic finite element models were compressed to 1% strain. This material property assignment method for computational models accurately reproduced the experimentally determined apparent modulus and concentrations of stress at locations of failure. (C) 2008 Elsevier Ltd. All rights reserved.
DOI 10.1016/j.jbiomech.2008.05.014
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