The factors potentially leading to the development of periodic hypoxia were investigated based on field studies performed over a series of two years between November, 1997 and November, 1999. This was attempted by investigating both hard and soft seafloor. Descriptive and predictive models were developed that incorporated physical, chemical and biological data derived from the present study and previous work and were used to anticipate future possible crashes of the faunal communities due to hypoxia/anoxia. It was concluded that periodic hypoxia at Ardbear is a natural event caused by several factors to varying degrees. The results of the present study indicate that the major controlling factors for oxygen depletion are the shallow depth of the system, coupled with the development of thermal stratification during periods of calm ambient meteorological conditions of the warmer summer months. In addition, a soft, muddy bottom and highly productive plankton blooms exacerbate conditions in a system already predisposed to hypoxia.