Peer-Reviewed Journal Details
Mandatory Fields
Rountree, JSS,Murphy, PV
2009
February
Organic Letters
Synthesis of a Novel Polyhydroxylated Salicylic Acid Lactone Framework
Published
()
Optional Fields
PRODUCT-LIKE SCAFFOLDS FORMAL TOTAL-SYNTHESIS SALICYLIHALAMIDE-A DRUG DISCOVERY V-ATPASE CHEMISTRY ANALOGS APICULAREN DIVERSITY MACROLIDE
11
871
874
The facile preparation of a novel 8-membered poly hydroxylated salicylic acid lactone from 2,6-dihydroxybenzoic acid and sodium thio-D-glucose is described. The key step involved a sodium hydride promoted intramolecular lactonization in the presence of excess TMSCl, which led to isolation of the "natural product like" lactone.
DOI 10.1021/ol802852r
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