Peer-Reviewed Journal Details
Mandatory Fields
Debnath, M,Doyle, KM,Langan, C,McDonald, C,Leonard, B,Cannon, DM
Translational Neuroscience
Recent Advances in Psychoneuroimmunology: Inflammation in Psychiatric Disorders
WOS: 15 ()
Optional Fields
Inflammation Cytokines Etiology Psychiatric disorders Neurotransmitter imbalance Maternal infections Apoptosis Brain Derived Neurotrophic Factor Hypothalamic Pituitary Adrenal Axis Glutamate Dopamine Serotonin Quinolinic acid Kynurenic acid NECROSIS-FACTOR-ALPHA ACUTE-PHASE PROTEINS C-REACTIVE PROTEIN FACTOR-KAPPA-B BIPOLAR AFFECTIVE-DISORDER OXIDE SYNTHASE EXPRESSION INDUCED SICKNESS BEHAVIOR INCREASED SERUM-LEVELS STRESSFUL LIFE EVENTS MAJOR DEPRESSION
Psychiatric disorders are common and complex and their precise biological underpinnings remain elusive. Multiple epidemiological, molecular, genetic and gene expression studies suggest that immune system dysfunction may contribute to the risk for developing psychiatric disorders including schizophrenia, bipolar disorder, and major depressive disorder. However, the precise mechanisms by which inflammation-related events confer such risk are unclear. In this review, we examine the peripheral and central evidence for inflammation in psychiatric disorders and the potential molecular mechanisms implicated including inhibition of neurogenesis, apoptosis, the HPA-axis, the role of brain-derived neurotrophic factor and the interplay between the glutamatergic, dopaminergic and serotonergic neurotransmitter systems.
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