Peer-Reviewed Journal Details
Mandatory Fields
Dong, YX,Saeed, AO,Hassan, W,Keigher, C,Zheng, Y,Tai, HY,Pandit, A,Wang, WX
2012
January
Macromolecular Rapid Communications
"One-step" Preparation of Thiol-Ene Clickable PEG-Based Thermoresponsive Hyperbranched Copolymer for In Situ Crosslinking Hybrid Hydrogel
Published
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Optional Fields
DE-ATRP hyperbranched polymer injectable hydrogel Michael-type addition thermoresponsive materials SYNTHETIC EXTRACELLULAR MATRICES HYALURONAN HYDROGELS DRUG-DELIVERY CELL POLYMERS BEHAVIOR SCAFFOLD INSULIN ACID RATS
33
120
126
A well-defined poly(ethylene glycol) based hyperbranched thermoresponsive copolymer with high content of acrylate vinyl groups was synthesized via a one-pot and one-step deactivation enhanced atom transfer radical polymerization approach, which provided an injectable and in situ crosslinkable system via Michael-type thiol-ene reaction with a thiol-modified hyaluronan biopolymer. The hyperbranched structure, molecular weight, and percentage of vinyl content of the copolymer were characterized by gel permeation chromatography and 1H NMR. The lower critical solution temperature of this copolymer is close to body temperature, which can result in a rapid thermal gelation at 37 degrees C. The scanning electron microscopy analysis of crosslinked hydrogel showed the network formation with porous structure, and 3D cell culture study demonstrated the good cell viability after the cells were embedded inside the hydrogel. This injectable and in situ crosslinking hybrid hydrogel system offers great promise as a new class of hybrid biomaterials for tissue engineering.
DOI 10.1002/marc.201100534
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