Other Publication Details
Mandatory Fields
Reviews
Sanz-Nogues, C;O'Brien, T
2016
September
In vitro models for assessing therapeutic angiogenesis
Published
1
Optional Fields
MESENCHYMAL STEM-CELLS CRITICAL LIMB ISCHEMIA MICROVASCULAR ENDOTHELIAL-CELLS ARTERIAL OCCLUSIVE DISEASE NEOVASCULARIZATION CAPACITY CARDIOVASCULAR-DISEASES 3-DIMENSIONAL COLLAGEN PROTEOMIC ANALYSIS PROGENITOR EXPRESSION
Arterial obstruction leading to ischemia causes a reduction of oxygen and nutrient supply to distal tissues. The physiological response to tissue ischemia triggers a cascade of events that results in the development of accessory vasculature to increase local tissue perfusion and to salvage tissue. However, this adaptive mechanism of repair is suboptimal in some patients. Therapeutic angiogenesis aims to stimulate new blood vessel formation via the local administration of proangiogenic agents or cell therapy products (CTPs). In this review, we provide a summary of the current understanding of in vitro models for assessing the angiogenic potential of a product.
OXFORD
ELSEVIER SCI LTD
1359-6446
1495
1503
10.1016/j.drudis.2016.05.016
Grant Details
Publication Themes