Peer-Reviewed Journal Details
Mandatory Fields
Sugihara, G,Kane, F,Picchioni, MM,Chaddock, CA,Kravariti, E,Kalidindi, S,Rijsdijk, F,Toulopoulou, T,Curtis, VA,McDonald, C,Murray, RM,McGuire, P
2017
May
European Neuropsychopharmacology
Effects of risk for bipolar disorder on brain function: A twin and family study
Published
Altmetric: 7WOS: 1 ()
Optional Fields
Bipolar disorder Functional magnetic resonance imaging Working memory Twin Genetic modeling WORKING-MEMORY TASK ENVIRONMENTAL-INFLUENCES 1ST-DEGREE RELATIVES VERBAL FLUENCY DEFAULT MODE ACTIVATION SCHIZOPHRENIA DYSFUNCTION MRI ABNORMALITIES
27
494
503
Bipolar disorder (BPD) is associated with altered regional brain function during the performance of cognitive tasks. The relative contribution of genetic and environmental risk factors for BPD to these changes has not yet been quantified. We sought to address this issue in a functional neuroimaging study of people who varied in their risk for BPD. Functional magnetic resonance imaging was used to study 124 subjects (29 twin and 9 sibling pairs with at least one member with BPD, and 24 healthy twin pairs) performing a working memory task. We assessed the influence of risk for BPD on regional brain function during the task in a two stage process. Firstly, we identified areas where there were group differences in activation. Secondly, we estimated the heritability and phenotypic correlation of activation and BPD using genetic modeling. BPD was associated with increased activation in the anterior cingulate, orbitofrontal, medial prefrontal, and left precentral cortices, and in the precuneus. Within these regions, activation in the orbitofrontal cortex rendered the most significant heritability estimate (h(2)=0.40), and was significantly correlated with BPD phenotype (r(ph)=0.29). A moderate proportion of the genetic influences (r(g)=0.69) acting on both BPD and on the degree of orbitofrontal activation were shared. These findings suggest that genetic factors that confer vulnerability to BPD alter brain function in BPD. (C) 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
10.1016/j.euroneuro.2017.03.001
Grant Details
Publication Themes