Book Chapter Details
Mandatory Fields
Karen Cawley, Shane Deegan, Afshin Samali, Sanjeev Gupta
2011 January
Methods in enzymology
The Unfolded Protein Response and Cellular Stress, Part 2
Elsevier Inc
UK
Published
1
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The endoplasmic reticulum (ER) is the site for folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the ER cause ER stress and activate a set of signaling pathways termed the unfolded protein response (UPR). The UPR leads to transcriptional activation of genes encoding ER-resident chaperones, oxidoreductases, and ER-associated degradation (ERAD) components.
0076-6879
10.1016/B978-0-12-385114-7.00002-7
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