Peer-Reviewed Journal Details
Mandatory Fields
Gabba, A,Robakiewicz, S,Taciak, B,Ulewicz, K,Broggini, G,Rastelli, G,Krol, M,Murphy, PV,Passarella, D
2017
January
European Journal Of Organic Chemistry
Synthesis and Biological Evaluation of Migrastatin Macrotriazoles
Published
()
Optional Fields
Macrocycles Triazoles Nitrogen heterocycles Click chemistry Bioisosteres Biological activity PACLITAXEL INHIBITORS ALDEHYDES DYNAMICS CELLS
2017
60
69
The synthesis of three macrotriazoles that are analogues of migrastatin is reported. The synthesis is based on copper(I)- and ruthenium-catalyzed azide-alkyne cycloaddition reactions. The enantiopure terminal alkyne derivatives were prepared by using the Trost desymmetrization, Brown alkoxy-allylation and an efficient Colvin reaction. Biological evaluation of the products revealed a promising efficiency in reducing the ability of MDA-MB-361 cell lines to migrate.
10.1002/ejoc.201600988
Grant Details
Publication Themes