Peer-Reviewed Journal Details
Mandatory Fields
Montagner, D., Fresch, B., Browne, K., Gandin, V., Erxleben, A.
2017
January
Chemical Communications
A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights
Published
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PERIPHERAL BENZODIAZEPINE-RECEPTOR SELECTIVE LIGANDS BINDING-AFFINITY 18 KDA TSPO CANCER SITES MODEL
53
134
137
A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.
10.1039/c6cc08100b
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