Book Chapter Details
Mandatory Fields
Aideen E Ryan, Mary M Murphy, Frank P Barry
2016 November
Biology and Therapeutic Applications of Mesenchymal Stromal Cells
Mesenchymal Stem/Stromal cell Therapy: mechanism of action and host response
Wiley Publishers
Optional Fields
The use of mesenchymal stem or stromal cells (MSCs) transplantation for tissue repair has received a great deal of attention in recent years, and these cells stand at the forefront of successful strategies in regenerative medicine. MSCs were first isolated from bone marrow by Friedenstein and described as adherent, colony forming fibroblastic cells with bone‐forming activity. Following the initial identification of MSCs from the bone marrow, studies focused on the regenerative capacity of MSCs based on their potential to transdifferentiate to cells of mesenchymal lineages. The ability of MSCs to home to sites of inflammation and adopt a distinct phenotype in response to the inflammatory microenvironment is crucial to our understanding of their therapeutic potential in acute and immune‐mediated diseases. Innate immune cells have important roles in tissue homeostasis and are the first line of defense against invading pathogens. MSC and innate immune cell interactions shape inflammatory and regenerative environments
Grant Details
Publication Themes
Biomedical Science and Engineering