Peer-Reviewed Journal Details
Mandatory Fields
Thomas, D., Gaspar, D., Sorushanova, A., Milcovich, G Spanoudes, K Mullen, AM; O'Brien, T; Pandit, A., Zeugolis, D.
2016
June
Biotechnology And Bioengineering
Scaffold and Scaffold-free Self-assembled Systems in Regenerative Medicine
Published
()
Optional Fields
cell-assembled devices; delivery of biologics; modular engineering; self-assembly; stimuli-responsive polymers; tissue engineering
113
6
1155
1163
Self-assembly in tissue engineering refers to the spontaneous chemical or biological association of components to form a distinct functional construct, reminiscent of native tissue. Such self-assembled systems have been widely used to develop platforms for the delivery of therapeutic and/or bioactive molecules and various cell populations. Tissue morphology and functional characteristics have been recapitulated in several self-assembled constructs, designed to incorporate stimuli responsiveness and controlled architecture through spatial confinement or field manipulation. In parallel, owing to substantial functional properties, scaffold-free cell-assembled devices have aided in the development of functional neotissues for various clinical targets. Herein, we discuss recent advancements and future aspirations in scaffold and scaffold-free self-assembled devices for regenerative medicine purposes.
Grant Details
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