Peer-Reviewed Journal Details
Mandatory Fields
Molloy, M,Comer, R,Rogers, P,Dowling, M,Meskell, P,Asbury, K,O'Leary, M
Irish Journal Of Medical Science
High risk HPV testing following treatment for cervical intraepithelial neoplasia
Optional Fields
Audit Cervical intraepithelial neoplasia Colposcopy HPV DNA tests Papanicolaou test LOOP EXCISION PREVENTION PREDICTION DISEASE
To determine the results of combined cytology and high-risk human papilloma virus (HR HPV) tests at 6 and 18 months postcolposcopy treatment at one Irish colposcopy centre.All women who attended the centre's colposcopy smear clinic for a co-test 6 months (initial test) posttreatment were included in the audit (n = 251).The results revealed negative HR HPV for 79 % (n = 198) of women tested 6 months after treatment and positive results for 21 % (n = 53). HR HPV testing was more sensitive than cytology and led to early detection of residual disease. No women with negative HR HPV had high-grade cytology.HR HPV is more sensitive than cytology for detection of persistent CIN. However, 19 women with positive HR HPV had normal colposcopy with no persistent CIN detected. A national cost-benefit analysis is recommended to determine the value of the second co-test.
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