Peer-Reviewed Journal Details
Mandatory Fields
Tabrizi, L,Golbang, R,Sadeghi, H,Chiniforoshan, H,Mcardle, P,Notash, B
2016
February
Journal Of Coordination Chemistry
Dinuclear cadmium indomethacin and Lawsone complexes: synthesis, crystal structures, antiproliferative and biological evaluations
Published
()
Optional Fields
Cadmium(II) complex indomethacin Lawsone DNA binding BSA binding cytotoxicity CD(II) POLYMERIC COMPLEX DNA-BINDING PROPERTIES CALF-THYMUS DNA METAL-COMPLEXES COBALT(II) COMPLEXES COORDINATION POLYMER TOLFENAMIC ACID MEFENAMIC-ACID SERUM-ALBUMIN CD2+ IONS
69
3021
3034
The synthesis and structural characterizations of Cd(II) indomethacin (Indo) and Lawsone (Law) complexes, K-2[Cd-2(Indo)(4)(SCN)(2)], 1 and [Cd-2(Law)(4)(phen)(2)]4CH(3)OH, 2 (SCN=thiocyanate, phen=1,10-phenanthroline), have been studied. The complexes are dimeric, structurally characterized by spectral (IR, TOF-Mass) and X-ray crystallography. The interaction of indomethacin and Lawsone ligands, 1 and 2 with calf thymus DNA and bovine serum albumin were investigated using UV-visible and fluorescence spectrophotometric methods. The in vitro cytotoxicity of 1 and 2 was examined against promyelocytic leukemia (HL-60), colon (HCT-8), brain (SF-295), and melanoma (MDA-MB-435) cancer cell lines. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria were tested.[GRAPHICS]
10.1080/00958972.2016.1223845
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