Conference Publication Details
Mandatory Fields
Ryder, A.G, Szczupak,B, Rotchev,Y.A, Klymchenko,A.S, Gorelov,A, Glynn,T.J.
OptoIreland 2005, published in: Proc SPIE - Int. Soc. Opt. Eng. vol. 5826
A fluorescence methodology for assessing the polarity and composition of novel thermoresponsive hydrophilic/hydrophobic copolymer system
2005
Unknown
Published
0
WOS: 1 ()
Optional Fields
Fluorescence, Polymer, thin-film.
1
11
Dublin, Ireland
The use of designed polymer coatings for specific applications such as drug delivery or modifying cell response is a critical aspect of medical device manufacturing. The chemical composition and physical characteristics of thin polymer coatings need to be analysed in-situ and this can present difficulties for traditional analytical methods. For example, changes in the polarity of polymer coatings are typically measured using the contact angle (CA) method. This is a simple process and gives good results however; it cannot be used to measure very hydrophilic polymers, or to analyse features smaller than a couple of mm in size. There is a need for a non-contact method for polarity measurement that issuitable for hydrophilic polymers on a macro- and microscopic scale. 4-diethylamino-3-hydroxyflavone (FE), 5, 6-benzo-4-diethylamino-3-hydroxyflavone (BFE), and 4-diethylamino-3-hydroxy-7-methoxyflavone (MFE) are fluorescence probes based on 3-hydroxyflavone. They respond to environment perturbations by shift and changes in the relative intensity of two well-separated bands in the emission spectra. These bands originate from an excited state intramolecular proton transfer (ESIPT) reaction. We have incorporated FE, BFE, and MFE into a novel thermoresponsive hydrophilic/hydrophobic copolymer system (NIPAM-NtBA) and studied its fluorescence behaviour. The fluorescence emission spectra depend strongly on copolymer composition, with increasing hydrophobicity (greater NtBA fraction) leading to a decrease in the value of log (IN*/IT*). This allows for the noncontact, measurement of the exact composition and surface energy of the copolymer system.
http://www.nuigalway.ie/nanoscale/documents/Conf-Papers/5826a1.pdf
10.1117/12.605117
Grant Details
This work was part supported by funding from the National Centre for Biomedical Engineering Science in NUI-Galway as part of the Higher Education Authority Programme for Research in Third Level Institutions, from NUI-Galway in the form of a fellowship to BS, and from Science Foundation Ireland under Grant number (02/IN.1/M231).
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