Peer-Reviewed Journal Details
Mandatory Fields
Vallejo-Giraldo, C,Pugliese, E,Larranaga, A,Fernandez-Yague, MA,Britton, JJ,Trotier, A,Tadayyon, G,Kelly, A,Rago, I,Sarasua, JR,Dowd, E,Quinlan, LR,Pandit, A,Biggs, MJP
2016
October
Nanomedicine
Polyhydroxyalkanoate/carbon nanotube nanocomposites: flexible electrically conducting elastomers for neural applications
Published
Altmetric: 1WOS: 10 ()
Optional Fields
elastomeric polymers MWCNTs neural interfaces PHA TISSUE ENGINEERING APPLICATIONS MECHANICAL-PROPERTIES CARBON NANOTUBES IN-VIVO STEM-CELLS RECORDING ELECTRODES INTERFACING NEURONS NEURITE OUTGROWTH GRAPHENE OXIDE STIMULATION
11
2547
2563
Aim: Medium chain length-polyhydroxyalkanoate/multi-walled carbon nanotube (MWCNTs) nanocomposites with a range of mechanical and electrochemical properties were fabricated via assisted dispersion and solvent casting, and their suitability as neural interface biomaterials was investigated. Materials & methods: Mechanical and electrical properties of medium chain length-polyhydroxyalkanoate/MWCNTs nanocomposite films were evaluated by tensile test and electrical impedance spectroscopy, respectively. Primary rat mesencephalic cells were seeded on the composites and quantitative immunostaining of relevant neural biomarkers, and electrical stimulation studies were performed. Results: Incorporation of MWCNTs to the polymeric matrix modulated the mechanical and electrical properties of resulting composites, and promoted differential cell viability, morphology and function as a function of MWCNT concentration. Conclusion: This study demonstrates the feasibility of a green thermoplastic MWCNTs nanocomposite for potential use in neural interfacing applications.
10.2217/nnm-2016-0075
Grant Details
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