Peer-Reviewed Journal Details
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Oommen, AM,Somaiya, N,Vijayan, J,Kumar, S,Venkatachalam, S,Joshi, L
2016
October
Journal Of Theoretical Biology
GlycoGAIT: A web database to browse glycogenes and lectins under gastric inflammatory diseases
Published
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Glycosylation Glycoscience Glycome genomics IBD H.pylori Gene expression analysis GLYCAN INTERACTIONS GENE-EXPRESSION BOWEL-DISEASE GLYCOSYLATION PROTEIN CANCER INNATE EPIDEMIOLOGY IMMUNITY MUCOSA
406
93
98
The perplexing nature of dynamic glycosylation modification plays imperative role in determining the regulatory role of key glycoconjugates involved in immune system. Systematic analysis of change in expression pattern of glycogenes and lectins can bring in a comprehensive understanding of genetic basis of the glycobiological changes occurring in pathological condition. Advancement in the field of glycobiology has capacitated the process of linking gene expression changes of glycogenes with its biological function. This instigated us to systematically analyze changes in expression patterns focusing on glycome genomics under diverse gastrointestinal immune dysfunction background. To necessitate this, as a pilot project, we carefully integrated several publically available databases to construct a glycosylation process associated gene set as well as public expression microarray data associated with gastrointestinal infections into an online database called Glycosylation and Gut Associated Immune Tolerance (GlycoGAIT). Currently the database comprises of 548 well characterized genes belonging to glycogenes and lectins along with gene expression data obtained from human biopsy samples under both H. pylori infection and inflammatory bowel disease (IBD) condition. The user-friendly interface enables the users to quickly compare and interpret changes in expression patterns of glycome genomics under different gut associated inflammatory conditions. The database is available online at: https://apps.connexios.com/glycogait/ (C) 2016 Elsevier Ltd. All rights reserved.
10.1016/j.jtbi.2016.07.020
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