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Moynihan, A. T., Hehir, M. P., Glavey, S. V. & Morrison, J. J.
2006
April
American Journal Of Obstetrics & Gynaecology
Inhibitory effect of leptin on human uterine contractility in vitro
Published
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Optional Fields
leptin myometrium maternal obesity parturition PREGNANT-WOMEN NORMAL-WEIGHT OBESE HUMANS SERUM LEPTIN RECEPTOR EXPRESSION DELIVERY COMPLICATIONS PREECLAMPSIA SECRETION
195
504
509
Objective: The purpose of this study was to investigate the effects of leptin on human uterine contractility in vitro.Study design: Biopsies of human myometrium were obtained at elective cesarean section (n = 18). Dissected myometrial strips suspended under isometric conditions, undergoing spontaneous and oxytocin-induced contractions, were exposed to cumulative additions of leptin in the concentration range of 1 nmol/L to 1 mu mol/L. Control strips were run simultaneously. Integrals of contractile activity were measured using the PowerLab hardware unit and Chart v3.6 software.Results: Leptin exerted a potent and cumulative inhibitory effect on spontaneous and oxytocin-induced contractions compared to control strips. The mean maximal inhibition values were as follows: 46.794 +/- 5.133% (n = 6; P < .001) for spontaneous contractions and 42.323 +/- 3.692% (n = 6; P < .001) for oxytocin-induced contractions. There was an apparent reduction in both frequency and amplitude of contractions.Conclusion: This physiologic inhibitory effect of leptin on uterine contractility may play a role in the dysfunctional labor process associated with maternal obesity, and the resultant high cesarean section rates. (c) 2006 Mosby, Inc. All rights reserved.
DOI 10.1016/j.ajog.2006.01.106
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