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Mandatory Fields
Roche, M., Diamond, M., Kelly, J. P. & Finn, D. P.
2006
June
Journal Of Neuroimmunology
Cannabinoid receptor-mediated modulation of lipopolysaccharide-induced alterations in brain and peripheral cytokine levels, circulating lymphocytes and hypothalamo-pituitary-adrenal axis activity in rats in vivo
Published
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Optional Fields
HU210 corticosterone SR141716A SR144528 IL-1 beta TNF alpha RAT MICROGLIAL CELLS CORTICOTROPIN-RELEASING-FACTOR MESSENGER-RNA EXPRESSION NITRIC-OXIDE PRODUCTION PITUITARY-ADRENAL AXIS NECROSIS-FACTOR-ALPHA RECEPTOR AGONIST ENDOCANNABINOID SYSTEM MULTIPLE-SCLEROSIS VANILLOID RECEPTORS
181
1-2
57
67
This study investigated cannabinoid receptor-mediated regulation of brain and peripheral cytokines in vivo. The cannabinoid receptor agonist, HU210 attenuated lipopolysaccharide (LPS)-induced increases in IL-1 beta and TNF alpha in rat brain and IL-1 beta, TNF alpha, IL-6 and IFN gamma in plasma. The CB1 receptor antagonist, SR141716A, attenuated the immunosupressive effects of HU210 on IL-1 beta, but not TNF alpha. SR141716A or the CB2 receptor antagonist, SR144528, alone attenuated LPS-induced cytokine increases. LPS and/or cannabinoids also reduced circulating lymphocyte numbers and increased corticosterone levels. These data provide evidence for modulation of pro-inflammatory cytokines in vivo by cannabinoid receptors and inform the development of cannabinoids for neuroinflammatory disorders. (c) 2006 Elsevier B.V. All rights reserved.
DOI 10.1016/j.jneuroim.2006.08.001
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