Peer-Reviewed Journal Details
Mandatory Fields
Rani, S,Ritter, T
2016
July
Advanced Materials
The Exosome - A Naturally Secreted Nanoparticle and its Application to Wound Healing
Published
()
Optional Fields
cell-free extracellular vesicles mesenchymal stem cells nanoparticles wound healing MESENCHYMAL STEM-CELLS DRUG-DELIVERY SYSTEMS EXTRACELLULAR VESICLES DENDRITIC CELLS CANCER-CELLS CLINICAL-APPLICATIONS ENHANCE ANGIOGENESIS MICRORNA DELIVERY GROWTH-FACTORS TUMOR-GROWTH
28
5542
5552
Wound healing is a complex process and often delayed in patients with underlying chronic conditions. The cost of wound care is a significant burden to the society, warranting new techniques to prompt wound healing. Several studies have reported on the beneficial effects of mesenchymal stem cells (MSCs) function in recruiting host cells, releasing secretory factors and matrix proteins thereby increasing wound heal. These secrete bioactive trophic factors from MSCs also includes extracellular vesicles (EVs) or exosomes. Recent studies have shown that EVs are one of the key secretory products of MSCs mediating cell-to-cell communication to enhance wound healing. Current knowledge related to the potential use of EVs in wound healing is reviewed and the promising future for EVs - a naturally secreted nanoparticle - as an alternative to cell-based therapy is discussed.
10.1002/adma.201504009
Grant Details
Health Research Board (HRB), Science Foundation Ireland (SFI)
Publication Themes