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Patti, A,Lambusta, D,Piattelli, M,Nicolosi, G,McArdle, P,Cunningham, D,Walsh, M
1997
January
Tetrahedron
Lipase-assisted preparation of enantiopure ferrocenyl sulfides possessing planar chirality and their use in the synthesis of chiral sulfoxides
Published
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STEREOSELECTIVE SYNTHESIS
53
1361
1368
Racemic 2-hydroxymethyl-1-phenylthioferrocene 5 and 2-hydroxymethyl-1-tert-butylthioferrocene 6 were subjected to kinetic resolution via acetylation catalysed by lipase from Candida antarctica (Novozym(R) 435) or Mucor miehei (Lipozyme(R)). The obtained enantiopure thioethers underwent chemical oxygenation at the sulfur atom to give the corresponding ferrocenyl sulfoxides with settled central/planar chirality. (C) 1997, Elsevier Science Ltd.
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