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Shen, Y,Connor, TJ,Kelly, JP,Leonard, BE
1999
May
Medical Science Research
Effects of chronic dietary supplementation with omega 3 and omega 6 fatty acid rich oils on lipopolysaccharide-induced behavioural responses and interleukin-1 beta secretion in the rat
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anhedonia behaviour cytokines depression fatty acids immune interleukin-1 beta lipopolysaccharide MAJOR DEPRESSION CHOLESTEROL
27
291
294
An abnormal fatty acid composition may be related to the immune-inflammatory pathophysiology of major depression. We have examined the effects of dietary supplementation (200 mg/kg per day) for 4 weeks with the omega 3 fatty acid rich oils eicosapentanoic acid (EPA) 70 monoester and EPA 95 diester or a omega 6 fatty acid rich oil, nicotinic gamma linoleic acid (Nico GLA) on lipopolysaccharide (LPS)-induced depressive-like behavioural symptoms and interleukin (IL)-1 beta production in the rat. LPS challenge (100 mu g/kg; i.p.) produced significant decreases in body weight gain, food intake, consumption of a palatable saccharin solution and nocturnal activity in the home cage in all groups irrespective of the nature of pre-treatment. The LPS challenge also provoked a robust increase in plasma interleukin-1 beta concentrations which was not altered by dietary fatty acid supplementation. These results suggest that dietary supplementation with either omega 3 or omega 6 fatty acids does not alter IL-1 beta secretion or the depressive-like behavioural symptoms provoked by LPS administration in the rat. Med Sci Res 27:291-294 (C) 1999 Lippincott Williams & Wilkins.
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