Peer-Reviewed Journal Details
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Zhou, Y,Murphy, PV
2010
October
Tetrahedron Letters
Synthesis of congeners of migrastatin and dorrigocin A from D-xylose
Published
()
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CELL-MIGRATION INHIBITORS WADSWORTH-EMMONS REACTION 1ST TOTAL-SYNTHESIS TUMOR-METASTASIS ETHYL (DIARYLPHOSPHONO)ACETATES ISO-MIGRASTATIN ANALOGS ANTIBIOTICS DISCOVERY ETHER
51
5262
5264
Migrastatin and dorrigocin A analogues have potential as anti-metastatic agents that act by targeting the actin-bundling protein, fascin. Syntheses of close structural analogues of these agents have been achieved. Wittig and Ando olefination reactions with an aldehyde obtained from D-xylose, respectively, gave two trisubstituted alkene intermediates that were then elaborated into either macrolactone or macrolactam analogues of migrastatin or to an acyclic dorrigocin A analogue. (C) 2010 Elsevier Ltd. All rights reserved.
DOI 10.1016/j.tetlet.2010.07.141
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