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Zhao, YX,Liu, M,Chagnault, V,Wang, JY,Zhang, XM,Murphy, PV
Bioorganic & Medicinal Chemistry Letters
Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold
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Peptidomimetic Somatostatin Angiogenesis Cell cycle Apoptosis Migration Stress fiber CELL-MIGRATION ANGIOGENESIS CANCER PEPTIDOMIMETICS DISCOVERY
Previously the synthesis of novel somatostatin mimetic from 1-deoxynojirimycin (DNJ) led to identification of a compound with affinity for human somatostatin receptor subtypes 4 and 5 (hSSTR4 and hSSTR5). Here we examined the properties of this peptidomimetic in a human umbilical vein endothelial cell (HUVEC) based assays. The peptidomimetic prevented capillary tube formation based on HUVECs. It also inhibited HUVEC proliferation by inducing G1 phase cell cycle arrest and apoptosis. Stress fiber assembly and cell migration in HUVECs was markedly suppressed by the somatostatin receptor ligand. (C) 2010 Elsevier Ltd. All rights reserved.
DOI 10.1016/j.bmcl.2010.11.088
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