Research findings suggest that switching between competing response sets can be resource demanding. The current study focused on concurrent health-relevant physiological effects of task switching by assessing cardiovascular response at varying levels of switch frequency. The participants performed a response-switching task at three different levels of response set switching frequency (low, medium and high) while measurements of blood pressure and heart rate were taken. One group was exposed to response-switching frequency conditions in the order low medium high, while the other group was exposed to the same task conditions in the reverse order (i.e. high medium low). The results showed that the participants in the low medium high switch frequency group recovered faster from initially heightened systolic blood pressure when compared with participants in the high medium low group. It is concluded that the results point to a physiological ocarry overo effect associated with beginning a task at rapid response switching frequency levels, and suggest the importance of habituation to task demands as a means of offsetting potentially unhealthy levels of reactivity. Implications for modern work environments are discussed.