Peer-Reviewed Journal Details
Mandatory Fields
Magni, P,Simeone, A,Healy, S,Isacchi, A,Bosotti, R
2011
September
Ieee-Acm Transactions On Computational Biology And Bioinformatics
Summarizing Probe Intensities of Affymetrix GeneChip 3 ' Expression Arrays Taking into Account Day-to-Day Variability
Published
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Optional Fields
Gene expression statistical analysis Affymetrix microarray experimental variability NORMALIZATION LEVEL
8
1425
1430
Microarray experiments are affected by several sources of variability. The paper demonstrates the major role of the day-to-day variability, it underlines the importance of a randomized block design when processing replicates over several days to avoid systematic biases and it proposes a simple algorithm that minimizes the day dependence.
DOI 10.1109/TCBB.2010.82
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