Peer-Reviewed Journal Details
Mandatory Fields
McCarthy, H,Waters, EM,Bose, JL,Foster, S,Bayles, KW,O'Neill, E,Fey, PD,O'Gara, JP
2016
May
Fems Microbiology Letters
The major autolysin is redundant for Staphylococcus aureus USA300 LAC JE2 virulence in a murine device-related infection model
Published
Optional Fields
Staphylococcus Autolysin biofilm device infection POLYSACCHARIDE INTERCELLULAR ADHESIN FIBRONECTIN-BINDING PROTEINS BIOFILM FORMATION MOLECULAR CHARACTERIZATION EPIDERMIDIS ATL PATHOGENESIS EXPRESSION PREVENTION MECHANISM
363
9
fnw087-
15
The major Staphylococcus aureus autolysin, Atl, has been implicated in attachment to surfaces and release of extracellular DNA during biofilm formation under laboratory conditions. Consistent with this, polyclonal antibodies to the amidase and glucosaminidase domains of Atl inhibited in vitro biofilm formation. However, in a murine model of device-related infection the community-associated S. aureus strain USA300 LAC JE2 established a successful infection in the absence of atl. These data indicate that Atl activity is not required for biofilm production in this infection model and reveal the importance of characterizing the contribution of biofilm phenotypes to virulence under in vivo conditions.
10.1093/femsle/fnw087
Grant Details
Publication Themes
Biomedical Science and Engineering