Peer-Reviewed Journal Details
Mandatory Fields
Ross, SA,Lane, JA,Kilcoyne, M,Joshi, L,Hickey, RM
2016
August
International Dairy Journal
Defatted bovine milk fat globule membrane inhibits association of enterohaemorrhagic Escherichia coli O157:H7 with human HT-29 cells
Published
WOS: 8 ()
Optional Fields
HELICOBACTER-PYLORI INFECTION IN-VIVO DIGESTION EPITHELIAL-CELLS OLIGOSACCHARIDES INHIBIT ROTAVIRUS REPLICATION H7 FLAGELLA ADHESION BINDING GLYCOPROTEINS ADHERENCE
59
36
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The bovine milk fat globule membrane (MFGM) is a source of food-derived glycans that can offer an approach to prevent Escherichia coli O157:H7 infection by inhibiting attachment of the pathogen to host cells. Such glycans may decrease the need for antibiotic treatment by acting as prophylactics. In this study, we generated a defatted bovine MFGM fraction, rich in proteins and glycoproteins, and demonstrated its ability to prevent the association of several enterohaemorrhagic E. coli O157: H7 strains with human colonic adenocarcinoma, HT-29 cells. This defatted MFGM fraction reduced bacterial association with HT-29 cells in a concentration dependent and strain specific manner. This study may present a new approach to mitigate the adverse health effects caused by E. coli infections in humans. (C) 2016 Elsevier Ltd. All rights reserved.
10.1016/j.idairyj.2016.03.001
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