Peer-Reviewed Journal Details
Mandatory Fields
Fuller, KP,Gaspar, D,Delgado, LM,Pandit, A,Zeugolis, DI
2016
March
Nanomedicine
Influence of porosity and pore shape on structural, mechanical and biological properties of poly epsilon-caprolactone electrospun fibrous scaffolds
Published
WOS: 16 ()
Optional Fields
controlled architecture scaffolds cytocompatibility electro-spinning mechanical properties scaffold design TISSUE-ENGINEERING APPLICATIONS EXTRUDED COLLAGEN-FIBERS IN-VITRO SUBSTRATE TOPOGRAPHY CELL INFILTRATION IMMUNE-RESPONSES VASCULAR GRAFTS DIAMETER NANOFIBERS MEMBRANES
11
1031
1040
Background: Electro-spun scaffolds are utilized in a diverse spectrum of clinical targets, with an ever-increasing quantity of work progressing to clinical studies and commercialization. The limited number of conformations in which the scaffolds can be fabricated hampers their wide acceptance in clinical practice. Materials & methods: Herein, we assessed a single-strep fabrication process for predesigned electro-spun scaffold preparation and the ramifications of the introduction of porosity (0, 30, 50, 70%) and pore shape (circle, rhomboid, square) on structural, mechanical (tensile and ball burst) and biological (dermal fibroblast and THP-1) properties. Results: The collector design did not affect the fibrous nature of the scaffold. Modulation of the porosity and pore shape offered control over the mechanical properties of the scaffolds. Neither the porosity nor the pore shape affected cellular (dermal fibroblast and THP-1) response. Conclusion: Overall, herein we provide evidence that electrospun scaffolds of controlled architecture can be fabricated with fibrous fidelity, adequate mechanical properties and acceptable cytocompatibility for a diverse range of clinical targets.
10.2217/nnm.16.21
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