Peer-Reviewed Journal Details
Mandatory Fields
Timashev, P,Kuznetsova, D,Koroleva, A,Prodanets, N,Deiwick, A,Piskun, Y,Bardakova, K,Dzhoyashvili, N,Kostjuk, S,Zagaynova, E,Rochev, Y,Chichkov, B,Bagratashvili, V
2016
April
Nanomedicine
Novel biodegradable star-shaped polylactide scaffolds for bone regeneration fabricated by two-photon polymerization
Published
WOS: 23 ()
Optional Fields
MSCs osteogenic differentiation star-shaped polylactide tissue engineering scaffolds two-photon polymerization (2PP) TISSUE ENGINEERING APPLICATIONS MESENCHYMAL STEM-CELLS MECHANICAL-PROPERTIES IN-VITRO DEGRADATION NETWORKS POLYCAPROLACTONE DIFFERENTIATION NANOCOMPOSITES STRATEGIES
11
1041
1053
Aim: To assess the properties of 3D biodegradable scaffolds fabricated from novel star-shaped poly(D,L-lactide) (SSL) materials for bone tissue regeneration. Materials & methods: The SSL polymer was synthesized using an optimized synthetic procedure and applied for scaffold fabrication by the two-photon polymerization technique. The osteogenic differentiation was controlled using human adipose-derived stem cells cultured for 28 days. The SSL scaffolds with or without murine MSCs were implanted into the cranial bone of C57/Bl6 mice. Results: The SSL scaffolds supported differentiation of human adipose-derived stem cells toward the osteogenic lineage in vitro. The SSL scaffolds with murine MSCs enhanced the mineralized tissue formation. Conclusion: The SSL scaffolds provide a beneficial microenvironment for the osteogenic MSCs' differentiation in vitro and support de novo bone formation in vivo.
10.2217/nnm-2015-0022
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