Conference Publication Details
Mandatory Fields
Subhash, HM,O'Gorman, S,Neuhaus, K,Leahy, M,Cote, GL
High resolution coherence domain depth-resolved nailfold capillaroscopy based on correlation mapping optical coherence tomography
OPTICAL DIAGNOSTICS AND SENSING XIV: TOWARD POINT-OF-CARE DIAGNOSTICS
2014
January
Published
1
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Optional Fields
Optical coherence tomography image processing Fourier domain interferometry biomedical optical imaging complex imaging optical angiography nailfold capillaroscopy optical interferometry SYSTEMIC-SCLEROSIS ABNORMALITIES
In this paper we demonstrate a novel application of correlation mapping optical coherence tomography (cm-OCT) for volumetric nailfold capillaroscopy (NFC). NFC is a widely used non-invasive diagnostic method to analyze capillary morphology and microvascular abnormalities of nailfold area for a range of disease conditions. However, the conventional NFC is incapable of providing volumetric imaging, when volumetric quantitative microangiopathic parameters such as plexus morphology, capillary density, and morphologic anomalies of the end row loops most critical. cm-OCT is a recently developed well established coherence domain magnitude based angiographic modality, which takes advantage of the time-varying speckle effect, which is normally dominant in the vicinity of vascular regions compared to static tissue region. It utilizes the correlation coefficient as a direct measurement of decorrelation between two adjacent B-frames to enhance the visibility of depth-resolved microcirculation.
10.1117/12.2038550
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