Conference Publication Details
Mandatory Fields
Deegan, BM,Sorond, FA,Lipsitz, LA,OLaighin, G,Serrador, JM,
2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20
Gender related differences in cerebral autoregulation in older healthy subjects
2009
September
Published
1
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Optional Fields
CEREBROVASCULAR CO2 REACTIVITY SEX-RELATED DIFFERENCES BLOOD-FLOW VELOCITY ANTERIOR
2859
2862
Cerebral autoregulation is an intrinsic mechanism of the cerebrovasculature that maintains cerebral blood flow relatively constant over a wide range of blood pressures. Recent studies have shown sex differences in cerebral autoregulation in adolescents and young adults. We evaluated cerebral auturegulation in 419 (186 male) subjects over the age of 70 recruited as part of the MOBILIZE Boston study. CO2 reactivity, transfer function gain and autoregulatory index (ARI) during sit to stand tests were assessed. Female subjects had significantly higher CO2 reactivity (p < 0.001) and vasomotor range (p<0.001) as well as ARI indices (p<0.001) and lower transfer function gain in the autoregulatory band (p=0.001), implying better cerebral autoregulation, than male subjects. The mechanisms of sex based differences in cerebral autoregulation remain unclear, but the results of this study highlight the need for future work to better understand these underlying autoregulatory differences.
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