Conference Publication Details
Mandatory Fields
Szczupak, B,Ryder, AG,Rochev, YA,Klymchenko, AS,Gorelov, A,Glynn, TJ,Byrne, HJ,Lewis, E,MacCraith, BD,McGlynn, E,McLaughlin, JA,OSullivan, GD,Ryder, AG,Walsh, JE
A fluorescence methodology for assessing the polarity and composition of novel thermoresponsive hydrophilic/hydrophobic copolymer system.
Opto-Ireland 2005: Optical Sensing and Spectroscopy
Optional Fields
fluorescence polymers polarity surface energy drug-eluting polymers 3-hydroxyflavone 3-HYDROXYCHROMONE 3-HYDROXYFLAVONE SOLVATOCHROMISM
The use of designed polymer coatings for specific applications such as drug delivery or modifying cell response is a critical aspect of medical device manufacturing. The chemical composition and physical characteristics of thin polymer coatings need to be analysed in-situ and this can present difficulties for traditional analytical methods.. For example, changes in the polarity of polymer coatings are typically measured using the contact angle (CA) method. This is a simple process and gives good results however; it cannot be used to measure very hydrophilic polymers, or to analyse features smaller than a couple of mm in size. There is a need for a non-contact method for polarity measurement that is suitable for hydrophilic polymers on a macro- and microscopic scale.4'-diethylamino-3-hydroxyflavone (FE), 5, 6-benzo-4'-diethylamino-3-hydroxyflavone (BFE), and 4'-diethylamino-3-hydroxy-7-methoxyflavone (MFE) are fluorescence probes based on 3-hydroxyflavone. They respond to environment perturbations by shift and changes in the relative intensity of two well-separated bands in the emission spectra. These bands originate from an excited state intramolecular proton transfer (ESIPT) reaction. We have incorporated FE, BFE, and MFE into a novel thermoresponsive hydrophilic/hydrophobic copolymer system (NIPAM-NtBA) and studied its fluorescence behaviour. The fluorescence emission spectra depend strongly on copolymer composition, with increasing hydrophobicity (greater NtBA fraction) leading to a decrease in the value Of 109 (I-N*/I-T*). This allows for the non-contact, measurement of the exact composition and surface energy of the copolymer system.
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