Employment is fundamental to the well-being of individuals including those with autism spectrum disorder (ASD). The purpose of this review is to provide an overview of employment-related research in individuals with ASD and increase our understanding of the factors that affect the employment situation of this population. Topics explored are employment outcomes revealed from adult outcome studies and national datasets as well as internal and external challenges that people with ASD may face in finding and maintaining employment. Social difficulties, comorbidity, education level, family support, employers’ attitudes, access to services and disability incentives have been implicated as factors that play an important role in predicting employment. Existing research evidence for specific employment training programs and strategies to successful employment are also introduced in regards to supported employment, transition services, assistive technology, and multidisciplinary collaboration. Finally, implications from both clinical practice and research perspective are provided.