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Boland, EL,Shine, R,Kelly, N,Sweeney, CA,McHugh, PE
2016
February
A Review of Material Degradation Modelling for the Analysis and Design of Bioabsorbable Stents
Published
1
Optional Fields
Finite element analysis Computational modelling Biodegradable stent Corrosion Polymer Hydrolysis Magnesium RESORBABLE DEVICE DEGRADATION BIODEGRADABLE POLYMERS MAGNESIUM ALLOYS DRUG-RELEASE IN-VITRO CARDIOVASCULAR STENTS CORONARY-ARTERIES POLY(LACTIC ACID) CORROSION MODEL METALLIC STENTS
The field of percutaneous coronary intervention has witnessed many progressions over the last few decades, more recently with the advancement of fully degradable bioabsorbable stents. Bioabsorbable materials, such as metallic alloys and aliphatic polyesters, have the potential to yield stents which provide temporary support to the blood vessel and allow native healing of the tissue to occur. Many chemical and physical reactions are reported to play a part in the degradation of such bioabsorbable materials, including, but not limited to, corrosion mechanisms for metals and the hydrolysis and crystallization of the backbone chains in polymers. In the design and analysis of bioabsorbable stents it is important to consider the effect of each aspect of the degradation on the material's in vivo performance. The development of robust computational modelling techniques which fully capture the degradation behaviour of these bioabsorbable materials is a key factor in the design of bioabsorable stents. A critical review of the current computational modelling techniques used in the design and analysis of these next generation devices is presented here, with the main accomplishments and limitations of each technique highlighted.
341
356
10.1007/s10439-015-1413-5
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