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Pires, ND,Bemer, M,Muller, LM,Baroux, C,Spillane, C,Grossniklaus, U
2016
January
Plos Genetics
Quantitative Genetics Identifies Cryptic Genetic Variation Involved in the Paternal Regulation of Seed Development
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Altmetric: 27WOS: 8 ()
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GENOME-WIDE ASSOCIATION ARABIDOPSIS-MEDEA LOCUS INBRED LINE POPULATION POLYCOMB GROUP GENE GROUP PROTEIN MEDEA ENDOSPERM DEVELOPMENT PARENTAL CONFLICT NATURAL VARIATION FLOWERING PLANTS THALIANA
12
Embryonic development requires a correct balancing of maternal and paternal genetic information. This balance is mediated by genomic imprinting, an epigenetic mechanism that leads to parent-of-origin-dependent gene expression. The parental conflict (or kinship) theory proposes that imprinting can evolve due to a conflict between maternal and paternal alleles over resource allocation during seed development. One assumption of this theory is that paternal alleles can regulate seed growth; however, paternal effects on seed size are often very low or non-existent. We demonstrate that there is a pool of cryptic genetic variation in the paternal control of Arabidopsis thaliana seed development. Such cryptic variation can be exposed in seeds that maternally inherit a medea mutation, suggesting that MEA acts as a maternal buffer of paternal effects. Genetic mapping using recombinant inbred lines, and a novel method for the mapping of parent-of-origin effects using whole-genome sequencing of segregant bulks, indicate that there are at least six loci with small, paternal effects on seed development. Together, our analyses reveal the existence of a pool of hidden genetic variation on the paternal control of seed development that is likely shaped by parental conflict.
10.1371/journal.pgen.1005806
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