Peer-Reviewed Journal Details
Mandatory Fields
DAVIS, AP,EGAN, TJ,ORCHARD, MG,CUNNINGHAM, D,MCARDLE, P
1992
October
Tetrahedron
THE STEREOSELECTIVE ADDITION OF ORGANOMETALLIC REAGENTS TO ELECTRON-DEFICIENT ALKYLIDENECYCLOHEXANES - ALTERNATIVE LINKAGES FOR CHOLAPHANE SYNTHESIS
Published
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Optional Fields
CONJUGATE ADDITION GRIGNARD-REAGENTS CHOLIC-ACID KETONES ESTERS RECOGNITION DERIVATIVES SYSTEM METAL
48
8725
8738
Knoevenagel condensations between t-butylcyclohexanone and malononitrile, Meldrum's acid and ethyl cyanoacetate gave electron-deficient alkenes which underwent equatorial-selective attack by chemoselective aryl organometallic reagents. Further transformations of the products were shown to be possible in some cases. The methodology is relevant to the synthesis of macrocyclic "cholaphane" receptors with externally-directed functional groups.
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Publication Themes