Peer-Reviewed Journal Details
Mandatory Fields
Shirazi, RN,Ronan, W,Rochev, Y,McHugh, P
2016
February
Journal Of The Mechanical Behavior Of Biomedical Materials
Modelling the degradation and elastic properties of poly(lactic-co-glycolic acid) films and regular open -cell tissue engineering scaffolds
Published
WOS: 9 ()
Optional Fields
PLGA Degradation Finite element modelling Tissue engineering scaffold Mechanical properties Size effect PHOSPHATE BUFFER SOLUTION IN-VITRO DEGRADATION HYDROLYTIC DEGRADATION BIODEGRADABLE POLYMERS PLGA MICROSPHERES POROUS SCAFFOLDS VIVO DEGRADATION CAST FILMS SIZE ARCHITECTURES
54
48
59
Scaffolding plays a critical rule in tissue engineering and an appropriate degradation rate and sufficient mechanical integrity are required during degradation and healing of tissue. This paper presents a computational investigation of the molecular weight degradation and the mechanical performance of poly(lactic-co-glycolic acid) (PLGA) films and tissue engineering scaffolds. A reaction-diffusion model which predicts the degradation behaviour is coupled with an entropy based mechanical model which relates Young's modulus and the molecular weight. The model parameters are determined based on experimental data for in-vitro degradation of a PLGA film. Microstructural models of three different scaffold architectures are used to investigate the degradation and mechanical behaviour of each scaffold. Although the architecture of the scaffold does not have a significant influence on the degradation rate, it determines the initial stiffness of the scaffold. It is revealed that the size of the scaffold strut controls the degradation rate and the mechanical collapse. A critical length scale due to competition between diffusion of degradation products and autocatalytic degradation is determined to be in the range 2-100 mu m. Below this range, slower homogenous degradation occurs; however, for larger samples monomers are trapped inside the sample and faster autocatalytic degradation occurs. (C) 2015 Elsevier Ltd. All rights reserved.
10.1016/j.jmbbm.2015.08.030
Grant Details
Publication Themes