Peer-Reviewed Journal Details
Mandatory Fields
Redmond, AM,Harkin, A,Kelly, JP,Leonard, BE
1999
January
European Neuropsychopharmacology
Effects of acute and chronic antidepressant administration on phencyclidine (PCP) induced locomotor hyperactivity
Published
()
Optional Fields
phencyclidine fluoxetine citalopram paroxetine sertraline locomotor activity NMDA RECEPTOR ANTAGONIST MESOLIMBIC DOPAMINE SYSTEM RAT-BRAIN NUCLEUS-ACCUMBENS DIZOCILPINE MK-801 CHANNEL COMPLEX DRUGS INCREASE BINDING-SITES SIGMA FLUOXETINE
9
165
170
Previously it was found that both acute and chronic antidepressant pre-treatment enhanced the locomotor hyperactivity induced by a challenge injection of the non-competitive NMDA receptor antagonist, dizocilpine (MK-801). In the present study the effects of acute and chronic antidepressant administration on phencyclidine (PCP)-induced locomotor hyperactivity were examined. Phencyclidine (PCP), a non-competitive NMDA receptor antagonist increased locomotor activity in rats. Fluoxetine given acutely increased and prolonged the PCP-induced locomotor hyperactivity, while citalopram, sertraline and paroxetine had no effect on the PCP-induced behavioural effect. Repeated treatment with fluoxetine, citalopram and paroxetine increased the PCP-induced locomotor hyperactivity. In contrast, chronic sertraline administration attenuated the locomotor response to a PCP challenge. These results indicate that these antidepressants which are presumed to have a similar pharmacological profile, differ in their ability to alter PCP-induced hyperactivity. Whether these differences have any bearing on the therapeutic or adverse effects of these drugs remains to be shown. (C) 1999 Elsevier Science B.V./ECNP. All rights reserved.
Grant Details
Publication Themes